MX-14-1
Macromolecular Crystallography 14.1
Publikationen
2024Charalampidou, A.; Nehls, T.; Meyners, C.; Gandhesiri, S.; Pomplun, S.; Pentelute, B.L.; Lermyte, F.; Hausch, F.: Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets. , ACS Central Science 10 (2024), p. 649-657
doi: 10.1021/acscentsci.3c01283
Zygowska, J.; Orlikowska, M.; Zhukov, I.; Szymanska, A.; Bal, W.: Copper interaction with cystatin C: effects on protein structure and oligomerization. , FEBS Journal 291 (2024), p. 1974-1991
doi: 10.1111/febs.17092
Dalwani, S.; Metz, A.; Huschmann, F.U.; Weiss, M.S.; Wierenga, R.K.; Venkatesan, R.: Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. , Acta Crystallographica Section D - Structural biology 80 (2024), p. 605-619
doi: 10.1107/s2059798324006557
Breidenbach, J.; Voget, R.; Si, Y.; Hingst, A.; Claff, T.; Sylvester, K.; Wolf, V.; Krasniqi, V.; Useini, A.; Straeter, N.; Ogura, Y.; Kawaguchi, A.; Mueller, C.E; Guetschow, M.: Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs. , Journal of Medicinal Chemistry 67 (2024), p. 8757-8790
doi: 10.1021/acs.jmedchem.4c00053
Spiwoková, P.; Horn, M.; Fanfrlík, J.; Jílková, A.; Fajtová, P.; Leontovyč, A.; Houštecká, R.; Bieliková, L.; Brynda, J.; Chanová, M.; Mertlíková-Kaiserová, H.; Caro-Diaz, E.J.E.; Almaliti, J.; El-Sakkary, N.; Gerwick, W.H.; Caffrey, C.R.; Mareš, M.: Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis. , ACS Infectious Diseases 10 (2024), p. 1935–1948
doi: 10.1021/acsinfecdis.3c00589
Martins, L.A.; Buša, M.; Chlastáková, A.; Kotál, J.; Beránková, Z.; Stergiou, N.; Jmel, M.A.; Schmitt, E.; Mareš, M.; Kotsyfakis, M.: Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host. , Cellular and Molecular Lilfe Sciences 80 (2024), p. 339/1-17
doi: 10.1007/s00018-023-04993-4
Lis, K.; Plewka, J.; Menezes, F.; Bielecka, E.; Chykunova, Y.; Pustelny, K.; Niebling, S.; Garcia, A.S.; Garcia-Alai, M.; Popowicz, G.M.; Nowak, J.S.; Czarna, A.; Kantyka, T.; Pyrc, K.: SARS-CoV-2 M pro oligomerization as a potential target for therapy. , International Journal of Biological Macromolecules 276 (2024), p. 133473/1
doi: 10.1016/j.ijbiomac.2024.133473
Roske, Y.; Cappel, C.; Cremer, N.; Hoffmann, P.; Koudelka, T.; Tholey, A.; Heinemann, U.; Daumke, O.; Damme, M.: Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation. , Nucleic Acids Research 52 (2024), p. 370-384
doi: 10.1093/nar/gkad1114
Data-doi: 10.5281/zenodo.10047708
Pentari, C.; Kosinas, C.; Nikolaivits, E.; Dimarogona, M.; Topakas, E.: Structural and molecular insights into a bifunctional glycoside hydrolase 30 xylanase specific to glucuronoxylan. , Biotechnology and Bioengineering 121 (2024), p. 2067-2078
doi: 10.1002/bit.28731
Wator, E.; Wilk, P.; Kochanowski, P.; Grudnik, P.: Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase. , FEBS Journal 291 (2024), p. 3856-3869
doi: 10.1111/febs.17207
Soltysová, M.; Skerlová, J.; Pachl, P.; Skubník, K.; Fábry, M.; Sieglová, I.; Farolfi, M.; Grishkovskaya, I.; Babiak, M.; Novácek, J.; Krásný, L.; Rezácová, P.: Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function. , Nucleic Acids Research 52 (2024), p. 7305-7320
doi: 10.1093/nar/gkae434
Brangulis, K.; Akopjana, I.; Bogans, J.; Kazaks, A.; Tars, K.: Structural studies of chromosomally encoded outer surface lipoprotein BB0158 from Borrelia burgdorferi sensu stricto. , Ticks and Tick-borne Diseases 15 (2024), p. 102287/1-9
doi: 10.1016/j.ttbdis.2023.102287
Useini, A.; Schwerin, I.K.; Kuenze, G.; Straeter, N.: Structural Studies on the Binding Mode of Bisphenols to PPARγ. , Biomolecules 14 (2024), p. 640/1-15
doi: 10.3390/biom14060640
Brangulis, K.; Drunka, L.; Akopjana, I.; Tars, K.: Structure of the Borrelia burgdorferi ATP-dependent metalloprotease FtsH in its functionally relevant hexameric form. , Biochimica et Biophysica Acta - Proteins and Proteomics 1872 (2024), p. 140969/1-8
doi: 10.1016/j.bbapap.2023.140969
Pentari, C.; Zerva, A.; Kosinas, C.; Karampa, P.; Puchart, V.; Dimarogona, M.; Topakas, E.: The role of CE16 exo-deacetylases in hemicellulolytic enzyme mixtures revealed by the biochemical and structural study of the novel TtCE16B esterase. , Carbohydrate Polymers 327 (2024), p. 121667/1-13
doi: 10.1016/j.carbpol.2023.121667
Buffa, V.; Meyners, C.; Sugiarto, W.O.; Bauder, M.; Gaali, S.; Hausch, F.: 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. , ChemMedChem 19 (2024), p. e202400264/1-23
doi: 10.1002/cmdc.202400264
van der Straat, R.; Draijer, R.; Surmiak, E.; Butera, R.; Land, L.; Magiera-Mularz, K.; Musielak, B.; Plewka, J.; Holak, T.A.; Dömling, A.: 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists. , RSC Medicinal Chemistry 15 (2024), p. 1210-1215
doi: 10.1039/d3md00746d
2023
Barthel, Tatjana: Crystallographic fragment screening - improvement of workflow, tools and procedures, and application for the development of enzyme and protein-protein interaction modulators. , FU Berlin, 2023
Job, Laura: Konstruktion und gentechnische Herstellung katalytischer Bioscavenger zur Detoxifizierung phosphororganischer Verbindungen. , TU München, 2023
Dimos, Nicole: Structural and biochemical characterization of biotechnologically relevant enzymes. , FU Berlin, 2023
Garbers, Tim Benedict: Structure-based Search for novel c-di-AMP Synthase Inhibiting Fragments. , Uni Göttingen, 2023
Mut, Jürgen: Synthese komplexer funktionaler Mono- und Oligosaccharid-Bausteine zur Untersuchung und Modifikation von Membranoberflächen humaner mesenchymaler Stromazellen. , Uni Würzburg, 2023
Truongvan, Ngoc: Understanding the dual specificity of UBA6. , Uni Würzburg, 2023
Foor, S.D.; Brangulis, K.; Shakya, A.K.; Rana, V.S.; Bista, S.; Kitsou, C.; Ronzetti, M.; Alreja, A.B.; Linden, S.B.; Altieri, A.S.; Baljinnyam, B.; Akopjana, I.; Nelson, D.C.; Simeonov, A.; Herzberg, O.; Caimano, M.J.; Pal, U.: A unique borrelial protein facilitates microbial immune evasion. , mBio 14 (2023), p. e02135-23/1-24
doi: 10.1128/mbio.02135-23
Busa, M.; Matouskova, Z.; Bartosova-Sojkova, P.; Pachl, P.; Rezacova, P.; Eichenberger, R.M.; Deplazes, P.; Horn, M.; Stefanic, S.; Mares, M.: An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily. , Journal of Biological Chemistry 299 (2023), p. 102970/1-14
doi: 10.1016/j.jbc.2023.102970
Borek, B.; Nowicka, J.; Gzik, A.; Dziegielewski, M.; Jedrzejczak, K.; Brzezinska, J.; Grzybowski, M.; Stanczak, P.; Pomper, P.; Zagozdzon, A.; Rejczak, T.; Matyszewski, K.; Golebiowski, A.; Olczak, J.; Lisiecki, K.; Tyszkiewicz, M.; Kania, M.; Piasecka, S.; Cabaj, A.; Dera, P.; Mulewski, K.; Chrzanowski, J.; Kusmirek, D.; Sobolewska, E.; Magdycz, M.; Mucha, L.; Masnyk, M.; Golab, J.; Nowotny, M.; Nowak, E.; Napiorkowska-Gromadzka, A.; Pikul, S.; Jazwiec, R.; Dzwonek, K.; Dobrzanski, P.; Meyring, M.; Skowronek, K.; Iwanowski, P.; Zaslona, Z.; Blaszczyk, R.: Arginase 1/2 inhibitor OATD-02: from discovery to first-in-man setup in cancer immunotherapy. , Molecular Cancer Therapeutics 22 (2023), p. 807–817
doi: 10.1158/1535-7163.mct-22-0721
Minniberger, S.; Abdolvand, S.; Braunbeck, S.; Sun, H.; Plested, A.J.R.: Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. , Journal of Molecular Biology : jmb 435 (2023), p. 167970/1-16
doi: 10.1016/j.jmb.2023.167970
Ivanova, J.N.; Nocentini, A.; Ta Rs, K.; Leita Ns, J.N.; Dvinskis, E.; Kazaks, A.; Domraceva, I.; Supuran, C.T.; Zalubovskis, R.: Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. , Journal of Medicinal Chemistry 66 (2023), p. 5703-5718
doi: 10.1021/acs.jmedchem.3c00007
Fanfrlík, J.; Brynda, J.; Kugler, M.; Lepsik, M.; Pospísilová, K.; Holub, J.; Hnyk, D.; Nekvinda, J.; Grüner, B.; Rezácová, P.: B–H⋯π and C–H⋯π interactions in protein-ligand complexes: carbonic anhydrase II inhibition by carborane sulfonamides. , Physical Chemistry Chemical Physics 25 (2023), p. 1728-1733
doi: 10.1039/d2cp04673c
Junghare, M.; Manavalan, T.; Fredriksen, L.; Leiros, I.; Altermark, B.; Eijsink, V.G.H.; Vaaje-Kolstad, G.: Biochemical and structural characterisation of a family GH5 cellulase from endosymbiont of shipworm P. megotara. , Biotechnology for Biofuels and Bioproducts 16 (2023), p. 61/1-15
doi: 10.1186/s13068-023-02307-1
Zink, Christoph: Biochemische und strukturbiologische Charakterisierung der Inhibition der Pyridoxal 5´-Phosphat Phosphatase durch 7,8-Dihydroxyflavon. , Dissertation, Würzburg, Universität Würzburg, 2023
doi: 10.25972/OPUS-25151
Navarrete, K.M.; Bumba, L.; Prudnikova, T.; Malcova, I.; Allsop, T.R.; Sebo, P.; Kamanova, J.: BopN is a Gatekeeper of the Bordetella Type III Secretion System. , Microbiology Spectrum 11 (2023), p. e04112-22/1-18
doi: 10.1128/spectrum.04112-22
Kovalova, M.; Havlicek, L.; Djukic, S.; Skerlova, J.; Perina, M.; Pospisil, T.; Reznickova, E.; Rezacova, P.; Jorda, R.; Krystof, V.: Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. , Biomedicine & Pharmacotherapy 161 (2023), p. 114492/1-9
doi: 10.1016/j.biopha.2023.114492
Kascakova, B.; Kotal, J.; Havlickova, P.; Vopatkova, V.; Prudnikova, T.; Grinkevich, P.; Kuty, M.; Chmelar, J.; Kuta Smatanova, I.: Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. , Acta Crystallographica Section D - Structural biology 79 (2023), p. 409-419
doi: 10.1107/s2059798323002322
Vester, K.; Metz, A.; Huber, S.; Loll, B.; Wahl, M.C.: Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. , Acta Crystallographica Section D - Structural biology 79 (2023), p. 304-317
doi: 10.1107/s2059798323001778
Wator, E.; Wilk, P.; Biela, A.; Rawski, M.; Zak, K.M.; Steinchen, W.; Bange, G.; Glatt, S.; Grudnik, P.: Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. , Nature Communications 14 (2023), p. 1698/1-14
doi: 10.1038/s41467-023-37305-2
Gardonyi, M.; Hasewinkel, C.; Wallbaum, J.; Wollenhaupt, J.; Weiss, M.S.; Klebe, G.; Reuter, K.; Heine, A.: Crystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC. , ACS Omega 8 (2023), p. 46051-46065
doi: 10.1021/acsomega.3c07058
Purder, P.L.; Meyners, C.; Sugiarto, W.O.; Kolos, J.; Lohr, F.; Gebel, J.; Nehls, T.; Dotsch, V.; Lermyte, F.; Hausch, F.: Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues. , JACS Au : an open access journal of the American Chemical Society 3 (2023), p. 2478-2486
doi: 10.1021/jacsau.3c00241
Gao, S.; Song, L.; Sylvester, K.; Mercorelli, B.; Loregian, A.; Toth, K.; Weisse, R.H.; Useini, A.; Straeter, N.; Yang, M.; Ye, B.; Tollefson, A.E.; Mueller, C.E.; Liu, X.; Zhan, P.: Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability. , Journal of Medicinal Chemistry 66 (2023), p. 16426-16440
doi: 10.1021/acs.jmedchem.3c01876
Skacel, J.; Djukic, S.; Baszczynski, O.; Kalcic, F.; Bilek, T.; Chalupsky, K.; Kozak, J.; Dvorakova, A.; Tloust'ova, E.; Kral'ova, Z.; Smidkova, M.; Voldrich, J.; Rumlova, M.; Pachl, P.; Brynda, J.; Vuckova, T.; Fabry, M.; Snasel, J.; Pichova, I.; Rezacova, P.; Mertlikova-Kaiserova, H.; Janeba, Z.: Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. , Journal of Medicinal Chemistry 66 (2023), p. 6652-6681
doi: 10.1021/acs.jmedchem.2c02097
Silhan, J.; Klima, M.; Otava, T.; Skvara, P.; Chalupska, D.; Chalupsky, K.; Kozic, J.; Nencka, R.; Boura, E.: Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. , Nature Communications 14 (2023), p. 2259/1-9
doi: 10.1038/s41467-023-38019-1
Sigurdsson, A.; Martins, B.M.; Düttmann, S.A.; Jasyk, M.; Dimos-Röhl, B.; Schöpf, F.; Gemander, M.; Knittel, C.H.; Schnegotzki, R.; Schmid, B.; Kosol, S.; Pommerening, L.; Gonzales-Viegaz, M.; Seidel, M.; Hügelland, M.; Leimkühler, S.; Dobbek, H.; Mainz, A.; Süssmuth, R.D.: Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL. , Angewandte Chemie - International Edition 62 (2023), p. e202302490/1-11
doi: 10.1002/anie.202302490
Kugler, M.; Hadzima, M.; Dzijak, R.; Rampmaier, R.; Srb, P.; Vrzal, L.; Voburka, Z.; Majer, P.; Rezacova, P.; Vrabel, M.: Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study. , RSC Medicinal Chemistry 14 (2023), p. 144-153
doi: 10.1039/d2md00330a
Hamre, A.G.; Al-Sadawi, R.; Johannesen, K.M.; Bisarro, B.; Kjendseth, A.R.; Leiros, H.S.; Sorlie, M.: Initial characterization of an iron superoxide dismutase from Thermobifida fusca. , Journal of Biological Inorganic Chemistry 28 (2023), p. 689-698
doi: 10.1007/s00775-023-02019-9
Schackert, F.K.; Biedermann, J.; Abdolvand, S.; Minniberger, S.; Song, C.; Plested, A.J.R.; Carloni, P.; Sun, H.: Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel. , Journal of Chemical Information and Modeling 63 (2023), p. 1293-1300
doi: 10.1021/acs.jcim.2c01494
Zuber, Philipp: Mechanistische Untersuchungen zur Regulation der bakteriellen Transkription durch NusG-Proteine. , Dissertation, 2020 , Universität Bayreuth, 2023
Abualrous, E.T.; Stolzenberg, S.; Sticht, J.; Wieczorek, M.; Roske, Y.; Gunther, M.; Dahn, S.; Boesen, B.B.; Calvo, M.M.; Biese, C.; Kuppler, F.; Medina-Garcia, A.; Alvaro-Benito, M.; Hofer, T.; Noe, F.; Freund, C.: MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange. , Nature Chemical Biology 19 (2023), p. 1196-1204
doi: 10.1038/s41589-023-01316-3
Adolph, R.S.; Beck, E.; Schweimer, K.; Di Fonzo, A.; Weyand, M.; Rosch, P.; Wöhrl, B.M.; Steegborn, C.: Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. , Life (Basel) 13 (2023), p. 949/1-17
doi: 10.3390/life13040949
Cowan, R.; Trokter, M.; Oleksy, A.; Fedorova, M.; Sawmynaden, K.; Worzfeld, T.; Offermanns, S.; Matthews, D.; Carr, M.D.; Hall, G.: Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signalling. , Journal of Biological Chemistry 299 (2023), p. 104740/1-16
doi: 10.1016/j.jbc.2023.104740
Füsser, F.T.; Wollenhaupt, J.; Weiss, M.S.; Kümmel, D.; Koch, O.: Novel starting points for fragment-based drug design against mycobacterial thioredoxin reductase identified using crystallographic fragment screening. , Acta Crystallographica Section D - Structural biology 79 (2023), p. 857-865
doi: 10.1107/s2059798323005223
Data-doi: 10.17879/40019550156
Data-doi: 10.17879/69998577695
Data-doi: 10.17879/39998753552
Nietzold, F.; Rubner, S.; Labuzek, B.; Golik, P.; Surmiak, E.; Del Corte, X.; Kitel, R.; Protzel, C.; Reppich-Sacher, R.; Stichel, J.; Magiera-Mularz, K.; Holak, T.A.; Berg, T.: Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group. , ChemBioChem 24 (2023), p. e202300006/1-6
doi: 10.1002/cbic.202300006
Heyder, L.; Hochban, P.M.M.; Taylor, C.; Chevillard, F.; Siefker, C.; Iking, C.; Borchardt, H.; Aigner, A.; Klebe, G.; Heine, A.; Kolb, P.; Diederich, W.E.: Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. , European Journal of Medicinal Chemistry 245 (2023), p. 114914/1-23
doi: 10.1016/j.ejmech.2022.114914
Tusar, L.; Loboda, J.; Impens, F.; Sosnowski, P.; Van Quickelberghe, E.; Vidmar, R.; Demol, H.; Sedeyn, K.; Saelens, X.; Vizovisek, M.; Mihelic, M.; Fonovic, M.; Horvat, J.; Kosec, G.; Turk, B.; Gevaert, K.; Turk, D.: Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. , Communications Biology 6 (2023), p. 450/1-15
doi: 10.1038/s42003-023-04772-8
Izhaki-Tavor, L.S.; Yechezkel, I.G.; Alter, J.; Dessau, M.: RNA Encapsulation Mode and Evolutionary Insights from the Crystal Structure of Emaravirus Nucleoprotein. , Microbiology Spectrum 11 (2023), p. e05018-22
doi: 10.1128/spectrum.05018-22
Sun, S.; Fushimi, M.; Rossetti, T.; Kaur, N.; Ferreira, J.; Miller, M.; Quast, J.; van den Heuvel, J.; Steegborn, C.; Levin, L.R.; Buck, J.; Myers, R.W.; Kargman, S.; Liverton, N.; Meinke, P.T.; Huggins, D.J.: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. , Journal of Chemical Information and Modeling 63 (2023), p. 2828-2841
doi: 10.1021/acs.jcim.2c01577
Grygier, P.; Pustelny, K.; Nowak, J.; Golik, P.; Popowicz, G.M.; Plettenburg, O.; Dubin, G.; Menezes, F.; Czarna, A.: Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective. , Journal of Medicinal Chemistry 66 (2023), p. 4009-4024
doi: 10.1021/acs.jmedchem.2c01887
Schmidt, A.; Kalms, J.; Lorent, C.; Katz, S.; Frielingsdorf, S.; Evans, R.M.; Fritsch, J.; Siebert, E.; Teutloff, C.; Armstrong, F.A.; Zebger, I.; Lenz, O.; Scheerer, P.: Stepwise conversion of the Cys6[4Fe-3S] to a Cys4[4Fe-4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase. , Chemical Science 14 (2023), p. 11105-11120
doi: 10.1039/d3sc03739h
Basak, Y.; Jeoung, J.H.; Domnik, L.; Dobbek, H.: Stepwise O2-Induced Rearrangement and Disassembly of the [NiFe4(OH)(μ3-S)4] Active Site Cluster of CO Dehydrogenase. , Angewandte Chemie - International Edition 62 (2023), p. e202305341/1-7
doi: 10.1002/anie.202305341
Nielipinski, M.; Pietrzyk-Brzezinska, A.; Wlodawer, A.; Sekula, B.: Structural analysis and molecular substrate recognition properties of Arabidopsis thaliana ornithine transcarbamylase, the molecular target of phaseolotoxin produced by Pseudomonas syringae. , Frontiers in Plant Science 14 (2023), p. 1297956/1-14
doi: 10.3389/fpls.2023.1297956
Pasch, T.; Schröder, A.; Kattelmann, S.; Eisenstein, M.; Pietrokovski, S.; Kümmel, D.; Mootz, H.D.: Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins. , Chemical Science 14 (2023), p. 5204-5213
doi: 10.1039/d3sc01200j
Szabo, E.; Nemes-Nikodem, E.; Vass, K.R.; Zambo, Z.; Zrupko, E.; Torocsik, B.; Ozohanics, O.; Nagy, B.; Ambrus, A.: Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase. , International Journal of Molecular Sciences 24 (2023), p. 10826/1-23
doi: 10.3390/ijms241310826
Sievers, Katharina: Structural and functional investigation of tRNA guanine transglycosylase. , Uni Göttingen, 2023
Kratky, J.; Eggerichs, D.; Heine, T.; Hofmann, S.; Sowa, P.; Weisse, R.H.; Tischler, D.; Sträter, N.: Structural and Mechanistical Studies on Substrate and Stereo Selectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and Sulfoxidations. , Angewandte Chemie - International Edition 62 (2023), p. e202300657/1-8
doi: 10.1002/anie.202300657
Skvara, P.; Chalupska, D.; Klima, M.; Kozic, J.; Silhan, J.; Boura, E.: Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39. , Antiviral Research 216 (2023), p. 105663/1-4
doi: 10.1016/j.antiviral.2023.105663
Useini, A.; Engelberger, F.; Künze, G.; Sträter, N.: Structural basis of the activation of PPAR gamma by the plasticizer metabolites MEHP and MINCH. , Environment International 173 (2023), p. 107822/1-11
doi: 10.1016/j.envint.2023.107822
Marcinkiewicz, A.L.; Brangulis, K.; Dupuis, A.P.; Hart, T.M.; Zamba-Campero, M.; Nowak, T.A.; Stout, J.L.; Akopjana, I.; Kazaks, A.; Bogans, J.; Ciota, A.T.; Kraiczy, P.; Kolokotronis, S.O.; Lin, Y.P.: Structural evolution of an immune evasion determinant shapes pathogen host tropism. , Proceedings of the National Academy of Sciences of the United States of America : PNAS 120 (2023), p. e2301549120/1-9
doi: 10.1073/pnas.2301549120
Petrovic, S.; Roske, Y.; Rami, B.; Phan, M.H.Q.; Panakova, D.; Heinemann, U.: Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. , Proceedings of the National Academy of Sciences of the United States of America : PNAS 120 (2023), p. e2208941120/1-12
doi: 10.1073/pnas.2208941120
Richter, P.K.; Blazquez-Sanchez, P.; Zhao, Z.; Engelberger, F.; Wiebeler, C.; Kuenze, G.; Frank, R.; Krinke, D.; Frezzotti, E.; Lihanova, Y.; Falkenstein, P.; Matysik, J.; Zimmermann, W.; Straeter, N.; Sonnendecker, C.: Structure and function of the metagenomic plastic-degrading polyester hydrolase PHL7 bound to its product. , Nature Communications 14 (2023), p. 1905/1-11
doi: 10.1038/s41467-023-37415-x
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Kober, F.X.; Koelmel, W.; Kuper, J.; Drechsler, J.; Mais, C.; Hermanns, H.M.; Schindelin, H.: The Crystal Structure of the Protein-Disulfide Isomerase Family Member ERp27 Provides Insights into Its Substrate Binding Capabilities. , Journal of Biological Chemistry 288 (2013), p. 2029-2039
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Xu, N.; Yu, S.; Moniot, S.; Weyand, M.; Blankenfeldt, W.: Crystallization and preliminary crystal structure analysis of the ligand-binding domain of PqsR (MvfR), the Pseudomonas quinolone signal (PQS) responsive quorum-sensing transcription factor of Pseudomonas aeruginosa. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 68 (2012), p. 1034-1039
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Hardegger, Leo Albert: Multidimensional approach towards the quantification of weak intermolecular interactions. , Zürich, Eidgenössische Technische Hochschule Zürich (ETH), Diss., 2012
Pflug, Alexander: Protein kinase selectivity mechanisms and structure assisted drug discovery. , Tromsø, University of Tromsø, thesis, 2012
Griessl, M.H.; Jungkunz, I.; Sonnewald, U.; Muller, Y.A.: Purification, crystallization and preliminary X-ray diffraction analysis of the Hsp40 protein CPIP1 from Nicotiana tabacum. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 68 (2012), p. 236-239
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Klinglmayr, E.; Wenger, J.; Mayr, S.; Bossy-Wetzel, E.; Puehringer, S.: Purification, crystallization and X-ray diffraction analysis of human dynamin-related protein 1 GTPase-GED fusion protein. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 68 (2012), p. 1217-1221
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Eibl, C.; Grigoriu, S.; Hessenberger, M.; Wenger, J.; Puehringer, S.; Pinheiro, A.S.; Wagner, R.N.; Proell, M.; Reed, J.C.; Page, R.; Diederichs, K.; Peti, W.: Structural and Functional Analysis of the NLRP4 Pyrin Domain. , Biochemistry 51 (2012), p. 7330-7341
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2011
Maestre-Martinez, M.; Haupt, K.; Edlich, F.; Neumann, P.; Parthier, C.; Stubbs, M.T.; Fischer, G.; Luecke, C.: A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding. , Journal of Molecular Recognition 24 (2011), p. 23-34
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Haupt, C.; Morgado, I.; Kumar, S.T.; Parthier, C.; Bereza, M.; Hortschansky, P.; Stubbs, M.T.; Horn, U.; Fändrich, M.: Amyloid Fibril Recognition with the Conformational B10 Antibody Fragment Depends on Electrostatic Interactions. , Journal of Molecular Biology : jmb 405 (2011), p. 341-348
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Venskutonyte, R.; Frydenvang, K.; Gajhede, M.; Bunch, L.; Pickering, D.S.; Kastrup, J.S.: Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. , Journal of Structural Biology 176 (2011), p. 307-314
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Bujacz, A.; Jedrzejczak-Krzepkowska, M.; Bielecki, S.; Redzynia, I.; Bujacz, G.: Crystal structures of the apo form of β-fructofuranosidase from Bifidobacterium longum and its complex with fructose. , FEBS Journal 278 (2011), p. 1728-1744
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Licht, A.; Bulut, H.; Scheffel, F.; Daumke, O.; Wehmeier, U.F.; Saenger, W.; Schneider, E.; Vahedi-Faridi, A.: Crystal structures of the bacterial solute receptor AcbH displaying an exclusive substrate preference for beta-D-galactopyranose. , Journal of Molecular Biology : jmb 406 (2011), p. 92-105
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Koharyova, M.; Brynda, J.; Rezacova, P.; Kollarova, M.: Crystallization and diffraction analysis of thioredoxin reductase from Streptomyces coelicolor. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 67 (2011), p. 917-921
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Sturm, K.U.; Griessl, M.H.; Wagner, C.; Deiwick, J.; Hensel, M.; Muller, Y.A.: Crystallization and preliminary crystallographic analysis of an Ig-domain-encompassing fragment of the giant adhesion protein SiiE from Salmonella enterica. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 67 (2011), p. 1371-1374
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Stsiapanava, A.; Chaloupkova, R.; Fortova, A.; Brynda, J.; Weiss, M.S.; Damborsky, J.; Kuta Smatanova, I.: Crystallization and preliminary X-ray diffraction analysis of the wild-type haloalkane dehalogenase DhaA and its variant DhaA13 complexed with different ligands. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 67 (2011), p. 253-257
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Koval, T.; Lipovova, P.; Podzimek, T.; Matousek, J.; Duskova, J.; Skalova, T.; Stepankova, A.; Hasek, J.; Dohnalek, J.: Crystallization of recombinant bifunctional nuclease TBN1 from tomato. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 67 (2011), p. 124-128
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Strube, C.P.; Homann, A.; Gamer, M.; Jahn, D.; Seibel, J.; Heinz, D.W.: Polysaccharide Synthesis of the Levansucrase SacB from Bacillus megaterium Is Controlled by Distinct Surface Motifs. , Journal of Biological Chemistry 286 (2011), p. 17593-17600
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Gao, S.; von der Malsburg, A.; Dick, A.; Faelber, K.; Schröder, G.F.; Haller, O.; Kochs, G.; Daumke, O.: Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function. , Immunity 35 (2011), p. 514-525
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Tarnawski, M.; Krzywda, S.; Bialek, W.; Jaskolski, M.; Szczepaniak, A.: Structure of the RuBisCO chaperone RbcX from the thermophilic cyanobacterium Thermosynechococcus elongatus. , Acta Crystallographica Section F - Structural Biology and Crystallization Communications 67 (2011), p. 851-857
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2009
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Helland, R.; Larsen, R.L.; Finstad, S.; Kyomuhendo, P.; Larsen, A.N.: Crystal structures of g-type lysozyme from Atlantic cod shed new light on substrate binding and the catalytic mechanism. , Cellular and Molecular Lilfe Sciences 66 (2009), p. 2585-2598
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Dengl, S.; Mayer, A.; Sun, M.; Cramer, P.: Structure and in vivo requirement of the yeast Spt6 SH2 domain. , Journal of Molecular Biology : jmb 389 (2009), p. 211-225
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2008
Helland, R.; Fjellbirkeland, A.; Karlsen, O.A.; Ve, T.; Lillehaug, J.R.; Jensen, H.B.: An Oxidized Tryptophan Facilitates Copper Binding in Methylococcus Capsulatus-Secreted Protein Mope. , Journal of Biological Chemistry 283 (2008), p. 13897-13904
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Yonus, H.; Neumann, P.; Zimmermann, S.; May, J.J.; Marahiel, M.A.; Stubbs, M.T.: Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. , Journal of Biological Chemistry 283 (2008), p. 32484-32491
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Vahedi-Faridi, A.; Eckey, V.; Scheffel, F.; Alings, C.; Landmesser, H.; Schneider, E.; Saenger, W.: Crystal structures and mutational analysis of the arginine-, lysine-, histidine-binding protein ArtJ from Geobacillus stearothermophilus. Implications for interactions of ArtJ with its cognate ATP-binding cassette transporter, Art(MP)2. , Journal of Molecular Biology : jmb 375 (2008), p. 448-459
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Zebisch, M.; Sträter, N.: Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling. , Proceedings of the National Academy of Sciences of the United States of America : PNAS 105 (2008), p. 6882-6887
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Tresaugues, L.; Stenmark, P.; Schüler, H.; Flodin, S.; Welin, M.; Nyman, T.; Hammarström, M.; Moche, M.; Gräslund, S.; Nordlund, P.: The Crystal Structure of Human Cleavage and Polyadenylation Specific Factor-5 Reveals a Dimeric Nudix Protein with a Conserved Catalytic Site. , Proteins - Structure, Function and Bioinformatics 73 (2008), p. 1047-1052
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Thorn, A.; Egerer-Sieber, C.; Jäger, C.; Herl, V.; Müller-Uri, F.; Kreis, W.; Muller, Y.A.: The Crystal Structure of Progesterone 5{Beta}-Reductase from Digitalis Lanata Defines a Novel Class of Short Chain Dehydrogenases/Reductases. , Journal of Biological Chemistry 283 (2008), p. 17260-17269
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Nyman, T.; Stenmark, P.; Flodin, S.; Johansson, I.; Hammarstrom, M.; Nordlund, P.: The Crystal Structure of the Human Toll-Like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer. , Journal of Biological Chemistry 283 (2008), p. 11861-11865
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Gurmu, D.; Lu, J.; Johnson, K.A.; Nordlund, P.; Holmgren, A.; Erlandsen, H.: The Crystal Structure of the Protein Yhak from Escherichia Coli Reveals a New Subclass of Redox Sensitive Enterobacterial Bicupins. , Proteins - Structure, Function and Bioinformatics 74 (2008), p. 18-31
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Ilari, A.; Bonamore, A.; Franceschini, S.; Fiorillo, A.; Boffi, A.; Colotti, G.: The X-Ray Structure of N-Methyltryptophan Oxidase Reveals the Structural Determinants of Substrate Specificity. , Proteins - Structure, Function and Bioinformatics 71 (2008), p. 2065-2075
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Schönfeld, D.L.; Ravelli, R.B.; Mueller, U.; Skerra, A.: The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin. , Journal of Molecular Biology : jmb 384 (2008), p. 393-405
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Ebersbach, H.; Fiedler, E.; Scheuermann, T.; Fiedler, M.; Stubbs, M.T.; Reimann, C.; Proetzel, G.; Rudolph, R.; Fiedler, U.: Affilin-Novel Binding Molecules Based on Human Gamma-B-Crystallin, an All Beta-Sheet Protein. , Journal of Molecular Biology : jmb 372 (2007), p. 172-185
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Max, K.E.; Zeeb, M.; Bienert, R.; Balbach, J.; Heinemann, U.: Common mode of DNA binding to cold shock domains : crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus. , FEBS Journal 274 (2007), p. 1265-1279
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